Sexual dimorphic miRNA-mediated response of bovine elongated embryos to the maternal microenvironment.

ABSTRACT: A skewed male-to-female ratio in cattle is believed to be due to the biased embryo losses during pregnancy. The changes in biochemical secretion such as miRNAs by the embryo due to altered maternal environment could cause a sex biased selective implantation resulting in a skewed male to female ratio at birth. Nevertheless, it is still not clear whether the male and female embryos could modify their miRNA expression patterns differently in response to altered physiological developmental conditions. Therefore, this study was focused on identifying sex specific miRNA expression patterns induced in the embryo during the elongation period in response to the maternal environment. For this, in vitro produced day female and male embryos were transferred to Holsteins Frisian cows and heifers. The e

SUBMITTER: Salilew-Wondim D 

PROVIDER: S-EPMC10903816 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature