Causal relationship between several autoimmune diseases and renal malignancies: A two-sample mendelian randomization study.

ABSTRACT:

Objective

Observational studies have shown an association between systemic autoimmune disease (AD) and multiple malignancies. However, due to the difficulty indetermining the temporal nature of the order, their causal relationship remains elusive. Based on pooled data from a large population-wide genome-wide association study (GWAS), this study explores the genetic causality between systemic autoimmune disease and renal malignancy.

Methods

We took a series of quality control steps from a large-scale genome-wide association study to select single nucleotide polymorphisms (SNPs) associated with systemic autoimmune disease as instrumental variables(IVs) to analyze genetic causality with renal malignancies. Inverse variance weighting (IVW), MR- Egger, weighted median, simple mod

SUBMITTER: Liu P 

PROVIDER: S-EPMC10903885 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature