Longitudinal analysis of host protein serum signatures of treatment and recovery in pulmonary tuberculosis.

ABSTRACT:

Background

A better understanding of treatment progression and recovery in pulmonary tuberculosis (TB) infectious disease is crucial. This study analyzed longitudinal serum samples from pulmonary TB patients undergoing interventional treatment to identify surrogate markers for TB-related outcomes.

Methods

Serum that was collected at baseline and 8, 17, 26, and 52 weeks from 30 TB patients experiencing durable cure were evaluated and compared using a sensitive LC-MS/MS proteomic platform for the detection and quantification of differential host protein signatures relative to timepoint. The global proteome signature was analyzed for statistical differences across the time course and between disease severity and treatment groups.

Results

A total of 676 proteins showed di

SUBMITTER: Powell SM 

PROVIDER: S-EPMC10903915 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature