Power-law behavior of transcriptional bursting regulated by enhancer-promoter communication.

ABSTRACT: Revealing how transcriptional bursting kinetics are genomically encoded is challenging because genome structures are stochastic at the organization level and are suggestively linked to gene transcription. To address this challenge, we develop a generic theoretical framework that integrates chromatin dynamics, enhancer-promoter (E-P) communication, and gene-state switching to study transcriptional bursting. The theory predicts that power law can be a general rule to quantitatively describe bursting modulations by E-P spatial communication. Specifically, burst frequency and burst size are up-regulated by E-P communication strength, following power laws with positive exponents. Analysis of the scaling exponents further reveals that burst frequency is preferentially regulated. Bursting kinetic

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10903953 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature