Natural history of blood pressure in sickle cell disease pregnancy.

ABSTRACT: In this retrospective cohort study of singleton pregnancies in people with sickle cell disease (SCD) delivered at two academic centres between 1990 and 2021, we collected demographic and SCD-related data, pregnancy outcomes, and the highest systolic and diastolic blood pressure (SBP and DBP) at seven time periods. We compared blood pressure values and trajectories in the composite cohort and in each genotype group to control values in a non-SCD pregnancy dataset. There were 290 pregnancies among 197 patients with SCD. Sixteen per cent (n = 47) of pregnancies had a hypertensive disorder of pregnancy (HDP); the rates did not differ by genotype. The mean SBP and DBP were lower in the HbSS/HbSβ⁰ group than in the non-SCD control group at all timepoints. Mean SBP and DBP trajectories

SUBMITTER: Early ML 

PROVIDER: S-EPMC10903988 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature