Dissemination of Circulating Tumor Cells in Breast and Prostate Cancer: Implications for Early Detection.

ABSTRACT: Burgeoning evidence suggests that circulating tumor cells (CTCs) may disseminate into blood vessels at an early stage, seeding metastases in various cancers such as breast and prostate cancer. Simultaneously, the early-stage CTCs that settle in metastatic sites [termed disseminated tumor cells (DTCs)] can enter dormancy, marking a potential source of late recurrence and therapy resistance. Thus, the presence of these early CTCs poses risks to patients but also holds potential benefits for early detection and treatment and opportunities for possibly curative interventions. This review delves into the role of early DTCs in driving latent metastasis within breast and prostate cancer, emphasizing the importance of early CTC detection in these diseases. We further explore the correlation betwee

SUBMITTER: Bae SY 

PROVIDER: S-EPMC10904107 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature