STING signalling compensates for low tumour mutation burden to drive anti-tumour immunity.

ABSTRACT:

Background

While mutation-derived neoantigens are well recognized in generating anti-tumour T cell response, increasing evidences highlight the complex association between tumour mutation burden (TMB) and tumour infiltrating lymphocytes (TILs). The exploration of non-TMB determinants of active immune response could improve the prognosis prediction and provide guidance for current immunotherapy.

Methods

The transcriptomic and whole exome sequence data in The Cancer Genome Atlas were used to examine the relationship between TMB and exhausted CD8+ T cells (Tex), as an indicator of tumour antigen-specific T cells across nine major cancer types. Computational clustering analysis was performed on 4510 tumours to identify different immune profiles. NanoString gene expression analys

SUBMITTER: Tan J 

PROVIDER: S-EPMC10904200 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature