Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.

ABSTRACT: Diabetic retinopathy (DR) is the most frequent microvascular complication of diabetes mellitus, however, its underlying biological mechanisms remain poorly understood. We examined single nucleotide polymorphisms linked to 486 blood metabolites through extensive genome-wide association studies conducted on individuals of European ancestry. The FinnGen Biobank database served as a reference to define DR. Two-sample MR analysis was conducted to reveal the association between the levels of genetically predicted circulating metabolites and the susceptibility to DR. To validate the robustness of the obtained findings, sensitivity analyses with weighted median, weighted mode, and MR-Egger were conducted. 1-oleoylglycerophosphoethanolamine (odds ratio [OR] (OR per one standard deviation [SD] incre

SUBMITTER: Ma L 

PROVIDER: S-EPMC10904376 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature