Denervation alters the secretome of myofibers and thereby affects muscle stem cell lineage progression and functionality.

ABSTRACT: Skeletal muscle function crucially depends on innervation while repair of skeletal muscle relies on resident muscle stem cells (MuSCs). However, it is poorly understood how innervation affects MuSC properties and thereby regeneration of skeletal muscle. Here, we report that loss of innervation causes precocious activation of MuSCs concomitant with the expression of markers of myogenic differentiation. This aberrant activation of MuSCs after loss of innervation is accompanied by profound alterations on the mRNA and protein level. Combination of muscle injury with loss of innervation results in impaired regeneration of skeletal muscle including shifts in myogenic populations concomitant with delayed maturation of regenerating myofibers. We further demonstrate that loss of innervation leads t

SUBMITTER: Henze H 

PROVIDER: S-EPMC10904387 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature