Unknown

Dataset Information

0

SDF-1 involvement in orthodontic tooth movement after tooth extraction.


ABSTRACT: The stromal cell-derived factor 1 (SDF-1)/chemokine receptor type 4 (CXCR4) axis plays a key role in alveolar bone metabolism during orthodontic tooth movement (OTM). Herein, the effects of the SDF-1/CXCR4 axis on the regional acceleratory phenomenon (RAP) in OTM velocity and on changes in the surrounding periodontium after adjacent tooth extraction in rats were investigated. Six-week-old male Wistar/ST rats underwent left maxillary first molar (M1) extraction and mesial OTM of the left maxillary second molar (M2) with a 10-g force closed-coil spring. Phosphate-buffered saline, immunoglobulin G (IgG) isotype control antibody, or anti-SDF-1 neutralizing monoclonal antibody were injected at the M1 and M2 interproximal areas (10 μg/0.1 mL) for the first three days. Analyses were performed after 1, 3, and 7 days (n = 7). The results demonstrated a significant increase in SDF-1 expression from day 1, which was effectively blocked via anti-SDF-1 neutralizing monoclonal antibody injection. On day 3, the M2 OTM distance and the number of positively stained osteoclasts significantly reduced alongside a reduction in inflammatory markers in the experimental group. Our results demonstrated that serial local injection of the anti-SDF-1 neutralizing monoclonal antibody reduces M2 OTM, osteoclast accumulation, and localized inflammatory responses in an OTM model with tooth extraction-induced RAP.

SUBMITTER: Rintanalert D 

PROVIDER: S-EPMC10904391 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications


The stromal cell-derived factor 1 (SDF-1)/chemokine receptor type 4 (CXCR4) axis plays a key role in alveolar bone metabolism during orthodontic tooth movement (OTM). Herein, the effects of the SDF-1/CXCR4 axis on the regional acceleratory phenomenon (RAP) in OTM velocity and on changes in the surrounding periodontium after adjacent tooth extraction in rats were investigated. Six-week-old male Wistar/ST rats underwent left maxillary first molar (M1) extraction and mesial OTM of the left maxillar  ...[more]

Similar Datasets

2025-04-09 | GSE246048 | GEO
2025-04-09 | GSE245975 | GEO
| S-EPMC6235963 | biostudies-literature
| S-EPMC3201678 | biostudies-other
| S-EPMC7193222 | biostudies-literature
| S-EPMC7235241 | biostudies-literature
| S-EPMC3775373 | biostudies-literature
| S-EPMC11456555 | biostudies-literature
| S-EPMC4293756 | biostudies-literature
| S-EPMC9000068 | biostudies-literature