Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children.

ABSTRACT:

Aims/hypothesis

Type 1 diabetes is an autoimmune disorder that is characterised by destruction of pancreatic beta cells by autoreactive T lymphocytes. Although islet autoantibodies (AAb) are an indicator of disease progression, specific immune biomarkers that can be used as target molecules to halt development of type 1 diabetes have not been discovered. Soluble immune checkpoint molecules (sICM) play a pivotal role in counteracting excessive lymphocyte responses, but their role in type 1 diabetes is unexplored. In this longitudinal study, we measured sICM levels in AAb-positive (AAb⁺) children to identify molecules related to type 1 diabetes progression.

Methods

We measured the levels of 14 sICM in the sera of AAb⁺ children (n=57) compared to those wit

SUBMITTER: Bruzzaniti S 

PROVIDER: S-EPMC10904438 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature