Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.

ABSTRACT:

Aim/hypothesis

The peroxisome proliferator-activated receptor-γ coactivator α (PGC-1α) plays a critical role in the maintenance of glucose, lipid and energy homeostasis by orchestrating metabolic programs in multiple tissues in response to environmental cues. In skeletal muscles, PGC-1α dysregulation has been associated with insulin resistance and type 2 diabetes but the underlying mechanisms have remained elusive. This research aims to understand the role of TET3, a member of the ten-eleven translocation (TET) family dioxygenases, in PGC-1α dysregulation in skeletal muscles in obesity and diabetes.

Methods

TET expression levels in skeletal muscles were analysed in humans with or without type 2 diabetes, as well as in mouse models of high-fat diet (HFD)-induced or geneticall

SUBMITTER: Liu B 

PROVIDER: S-EPMC10904493 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature