The effect of dose-interval on antibody response to mRNA COVID-19 vaccines: a prospective cohort study.

ABSTRACT:

Background

Vaccination against COVID-19 is highly effective in preventing severe disease and hospitalization, but primary COVID mRNA vaccination schedules often differed from those recommended by the manufacturers due to supply chain issues. We investigated the impact of delaying the second dose on antibody responses to COVID mRNA-vaccines in a prospective cohort of health-care workers in Quebec.

Methods

We recruited participants from the McGill University Health Centre who provided serum or participant-collected dried blood samples (DBS) at 28-days, 3 months, and 6 months post-second dose and at 28-days after a third dose. IgG antibodies to SARS-CoV2 spike (S), the receptor-binding domain (RBD), nucleocapsid (N) and neutralizing antibodies to the ancestral strain were asses

SUBMITTER: Almeida ND 

PROVIDER: S-EPMC10904688 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature