A Systematic Literature Review on Risk Factors for and Timing of Clostridioides difficile Infection in the United States.

ABSTRACT:

Introduction

Clostridioides difficile infection (CDI) is a major public health threat. Up to 40% of patients with CDI experience recurrent CDI (rCDI), which is associated with increased morbidity. This study aimed to define an at-risk population by obtaining a detailed understanding of the different factors leading to CDI, rCDI, and CDI-related morbidity and of time to CDI.

Methods

We conducted a systematic literature review (SLR) of MEDLINE (using PubMed) and EMBASE for relevant articles published between January 1, 2016, and November 11, 2022, covering the US population.

Results

Of the 1324 articles identified, 151 met prespecified inclusion criteria. Advanced patient age was a likely risk factor for primary CDI within a general population, with significant risk est

SUBMITTER: Eeuwijk J 

PROVIDER: S-EPMC10904710 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature