The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021.

ABSTRACT:

Background

HIV-1 drug resistance is a huge challenge in the era of ART.

Objectives

To investigate the prevalence and characteristics of acquired HIV-1 drug resistance (ADR) in Shanghai, China.

Methods

An epidemiological study was performed among people living with human immunodeficiency virus (PLWH) receiving ART in Shanghai from January 2017 to December 2021. A total of 8669 PLWH were tested for drug resistance by genotypic resistance testing. Drug resistance mutations (DRMs) were identified using the Stanford University HIV Drug Resistance Database program.

Results

Ten HIV-1 subtypes/circulating recombinant forms (CRFs) were identified, mainly including CRF01_AE (46.8%), CRF07_BC (35.7%), B (6.4%), CRF55_01B (2.8%) and CRF08_BC (2.4%). The prevalence of ADR w

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10904715 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature