Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial.

ABSTRACT: Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive either placebo or prebiotic daily for 12 weeks. Resistance exercise and branched chain amino acid (BCAA) supplementation is prescribed to all participants. Outcomes are physical function and cognition. The trial is carried out remotely using video visits, online questionnaires and cognitive testing, and posting of equipment and biological samples. The prebiotic supplement is well tolerated and results in a changed gut microbiome [e.

SUBMITTER: Ni Lochlainn M 

PROVIDER: S-EPMC10904794 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature