Elucidating hepatocellular carcinoma progression: a novel prognostic miRNA-mRNA network and signature analysis.

ABSTRACT: There is increasing evidence that miRNAs play an important role in the prognosis of HCC. There is currently a lack of acknowledged models that accurately predict patient prognosis. The aim of this study is to create a miRNA-based model to precisely forecast a patient's prognosis and a miRNA-mRNA network to investigate the function of a targeted mRNA. TCGA miRNA dataset and survival data of HCC patients were downloaded for differential analysis. The outcomes of variance analysis were subjected to univariate and multivariate Cox regression analyses and LASSO analysis. We constructed and visualized prognosis-related models and subsequently used violin plots to probe the function of miRNAs in tumor cells. We predicted the target mRNAs added those to the String database, built PPI protein inter

SUBMITTER: Wang F 

PROVIDER: S-EPMC10904818 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature