Maternal COVID-19 Vaccination and Prevention of Symptomatic Infection in Infants.

ABSTRACT:

Background and objectives

Maternal vaccination may prevent infant coronavirus disease 2019 (COVID-19). We aimed to quantify protection against infection from maternally derived vaccine-induced antibodies in the first 6 months of an infant's life.

Methods

Infants born to mothers vaccinated during pregnancy with 2 or 3 doses of a messenger RNA COVID-19 vaccine (nonboosted or boosted, respectively) had full-length spike (Spike) immunoglobulin G (IgG), pseudovirus 614D, and live virus D614G, and omicron BA.1 and BA.5 neutralizing antibody (nAb) titers measured at delivery. Infant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was determined by verified maternal-report and laboratory confirmation through prospective follow-up to 6 months of age between Dec

SUBMITTER: Cardemil CV 

PROVIDER: S-EPMC10904887 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature