Identification of recurrent BRAF non-V600 mutations in intraductal carcinoma of the prostate in Chinese populations.

ABSTRACT: While BRAF alterations have been established as a driver in various solid malignancies, the characterization of BRAF alterations in prostate cancer (PCa) has not been thoroughly interrogated. By bioinformatics analysis, we first found that BRAF alterations were associated with advanced PCa and exhibited mutually exclusive pattern with ERG alteration across multiple cohorts. Of the most interest, recurrent non-V600 BRAF mutations were found in 3 of 21 (14.3 %) PCa patients demonstrating IDC-P morphology. Furthermore, experimental overexpression of BRAF^K601E and BRAF^L597R exhibited emergence of oncogenic phenotypes with intensified MAPK signaling in vitro, which could be targeted by MEK inhibitors. Comparison of the incidence of BRAF alterations in IDC-P between western

SUBMITTER: Hu J 

PROVIDER: S-EPMC10904907 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature