Direct three-dimensional segmentation of prostate glands with nnU-Net.

ABSTRACT:

Significance

In recent years, we and others have developed non-destructive methods to obtain three-dimensional (3D) pathology datasets of clinical biopsies and surgical specimens. For prostate cancer risk stratification (prognostication), standard-of-care Gleason grading is based on examining the morphology of prostate glands in thin 2D sections. This motivates us to perform 3D segmentation of prostate glands in our 3D pathology datasets for the purposes of computational analysis of 3D glandular features that could offer improved prognostic performance.

Aim

To facilitate prostate cancer risk assessment, we developed a computationally efficient and accurate deep learning model for 3D gland segmentation based on open-top light-sheet microscopy datasets of human prostate biopsi

SUBMITTER: Wang R 

PROVIDER: S-EPMC10905031 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature