Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon.

ABSTRACT:

Background & aims

Chronic inflammatory illnesses are debilitating and recurrent conditions associated with significant comorbidities, including an increased risk of developing cancer. Extensive tissue remodeling is a hallmark of such illnesses, and is both a consequence and a mediator of disease progression. Despite previous characterization of epithelial and stromal remodeling during inflammatory bowel disease, a complete understanding of its impact on disease progression is lacking.

Methods

A comprehensive proteomic pipeline using data-independent acquisition was applied to decellularized colon samples from the Muc2 knockout (Muc2^KO) mouse model of colitis for an in-depth characterization of extracellular matrix remodeling. Unique proteomic profiles of the matri

SUBMITTER: Moutin EB 

PROVIDER: S-EPMC10905044 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature