Contribution of Matrix Metalloproteinase-2 Genotypes to Taiwan Pterygium Risk.

ABSTRACT:

Background/aim

In the literature, the studies about the role of matrix metalloproteinase-2 (MMP-2) in pterygium diagnosis are mainly based on its protein expression. The role of MMP-2 variants has never been examined. The aim of this study was to examine the association of MMP-2 genotypes with pterygium risk.

Materials and methods

MMP-2 rs243865 and rs2285053 were genotyped in 140 pterygium cases and 280 non-pterygium controls by typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping technology.

Results

The genotypic frequency of MMP-2 rs243865 CC, CT and TT were 86.4%, 12.9% and 0.7% in the pterygium group and 81.1%, 17.1% and 1.8% in the non-pterygium group (p for trend=0.3389). The variant CT and TT carriers had a 0.70- and

SUBMITTER: Hu PS 

PROVIDER: S-EPMC10905486 | biostudies-literature | 2024 Mar-Apr

REPOSITORIES: biostudies-literature