IVF versus IUI with ovarian stimulation for unexplained infertility: a collaborative individual participant data meta-analysis.

ABSTRACT:

Background

IVF and IUI with ovarian stimulation (IUI-OS) are widely used in managing unexplained infertility. IUI-OS is generally considered first-line therapy, followed by IVF only if IUI-OS is unsuccessful after several attempts. However, there is a growing interest in using IVF for immediate treatment because it is believed to lead to higher live birth rates and shorter time to pregnancy.

Objective and rationale

Randomized controlled trials (RCTs) comparing IVF versus IUI-OS had varied study designs and findings. Some RCTs used complex algorithms to combine IVF and IUI-OS, while others had unequal follow-up time between arms or compared treatments on a per-cycle basis, which introduced biases. Comparing cumulative live birth rates of IVF and IUI-OS within a consistent tim

SUBMITTER: Lai S 

PROVIDER: S-EPMC10905504 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature