Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies.

ABSTRACT:

Background

Clinical, molecular, and genetic epidemiology studies displayed remarkable differences between ever- and never-smoking lung cancer.

Methods

We conducted a stratified multi-population (European, East Asian, and African descent) association study on 44,823 ever-smokers and 20,074 never-smokers to identify novel variants that were missed in the non-stratified analysis. Functional analysis including expression quantitative trait loci (eQTL) colocalization and DNA damage assays, and annotation studies were conducted to evaluate the functional roles of the variants. We further evaluated the impact of smoking quantity on lung cancer risk for the variants associated with ever-smoking lung cancer.

Results

Five novel independent loci, GABRA4, intergenic region 12q24.

SUBMITTER: Li Y 

PROVIDER: S-EPMC10905670 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature