Interactions of obesity, body shape, diabetes and sex steroids with respect to prostate cancer risk in the UK Biobank cohort.

ABSTRACT:

Background

Obesity and diabetes are associated inversely with low-grade prostate cancer risk and affect steroid hormone synthesis but whether they modify each other's impact on prostate cancer risk remains unknown.

Methods

We examined the independent associations of diabetes, body mass index (BMI), 'a body shape index' (ABSI), hip index (HI), circulating testosterone, sex hormone binding globulin (SHBG) (per one standard deviation increase) and oestradiol ≥175 pmol/L with total prostate cancer risk using multivariable Cox proportional hazards models for UK Biobank men. We evaluated multiplicative interactions (p_MI ) and additive interactions (relative excess risk from interaction (p_RERI ), attributable proportion (p_AR ), synergy index (p

SUBMITTER: Christakoudi S 

PROVIDER: S-EPMC10905680 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature