Cholesterols Induced Distinctive Entry of the Graphene Nanosheet into the Cell Membrane.

ABSTRACT: Graphene nanosheets are highly valued in the biomedical field due to their potential applications in drug delivery, biological imaging, and biosensors. Their biological effects on mammalian cells may be influenced by cholesterols, which are crucial components in cell membranes that take part in many vital processes. Therefore, it is particularly important to investigate the effect of cholesterols on the transport mechanism of graphene nanosheets in the cell membrane as well as the final stable configuration of graphene, which may have an impact on cytotoxicity. In this paper, the molecular details of a graphene nanosheet interacting with a 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine (DPPC) membrane with cholesterols were studied using molecular dynamics simulations. Results showe

SUBMITTER: Tan B 

PROVIDER: S-EPMC10905697 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature