Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.

ABSTRACT:

Background

The clinical manifestations of COVID-19 range from asymptomatic, mild to moderate, severe, and critical disease. Host genetic variants were recognized to affect the disease severity. However, the genetic landscape differs among various populations. Therefore, we explored the variants associated with COVID-19 severity in the Guangdong population.

Methods

A total of 314 subjects were selected, of which the severe and critical COVID-19 patients were defined as "cases", and the mild and moderate patients were defined as "control". Twenty-two variants in interferon-related genes and FOXP4 were genotyped using the MassARRAY technology platform.

Results

IFN signaling gene MX1 rs17000900 CA + AA genotype was correlated with a reduced risk of severe COVID-19 in male

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10905836 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature