GMP-manufactured CRISPR/Cas9 technology as an advantageous tool to support cancer immunotherapy.

ABSTRACT:

Background

CRISPR/Cas9 system to treat human-related diseases has achieved significant results and, even if its potential application in cancer research is improving, the application of this approach in clinical practice is still a nascent technology.

Main body

CRISPR/Cas9 technology is not yet used as a single therapy to treat tumors but it can be combined with traditional treatment strategies to provide personalized gene therapy for patients. The combination with chemotherapy, radiation and immunotherapy has been proven to be a powerful means of screening, identifying, validating and correcting tumor targets. Recently, CRISPR/Cas9 technology and CAR T-cell therapies have been integrated to open novel opportunities for the production of more efficient CAR T-cells for all pa

SUBMITTER: Caforio M 

PROVIDER: S-EPMC10905844 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature