The influence of placenta microbiota of normal term pregnant women on immune regulation during pregnancy.

ABSTRACT:

Background

The concerted regulation of placenta microbiota and the immune responses secures the occurrence and development of pregnancy, while few studies reported this correlation. This study aimed to explore the relationship between the placenta microbiota and immune regulation during pregnancy.

Methods

Twenty-six healthy pregnant women scheduled for elective cesarean section in the First Affiliated Hospital of Jinan University who met the inclusion criteria were recruited. Placenta and peripheral venous blood samples were collected. Microbiota in placental tissue was detected using high-throughput sequencing. Flow cytometry was used to detect immune cells in placental tissue and peripheral venous blood. ELISA and Luminex liquid chip technology were used to detect the cont

SUBMITTER: Yang P 

PROVIDER: S-EPMC10905846 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature