Targeting beta-adrenergic receptor pathways in melanoma: how stress modulates oncogenic immunity.

ABSTRACT: The intricate pathways of the sympathetic nervous system hold an inherently protective role in the setting of acute stress. This is achieved through dynamic immunomodulatory and neurobiological networks. However, excessive and chronic exposure to these stress-induced stimuli appears to cause physiologic dysfunction through several mechanisms that may impair psychosocial, neurologic, and immunologic health. Numerous preclinical observations have identified the beta-2 adrenergic receptor (β2-AR) subtype to possess the strongest impact on immune dysfunction in the setting of chronic stressful stimuli. This prolonged expression of β2-ARs appears to suppress immune surveillance and promote tumorigenesis within multiple cancer types. This occurs through several pathways, including (1) decreasing

SUBMITTER: Switzer B 

PROVIDER: S-EPMC10906201 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature