Functional hypoxia reduces mitochondrial calcium uptake.

ABSTRACT: Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate hub for coordinating cellular adaption to changes in oxygen levels. How changes in respiration under functional hypoxia (i.e., when intracellular O₂ levels limit mitochondrial respiration) are relayed by the electron transfer system to impact mitochondrial adaption and remodeling after hypoxic exposure remains poorly defined. This is largely due to challenges integrating findings under controlled and defined O₂ levels in studies connecting functions of isolated mitochondria to humans during physical exercise. Here we

SUBMITTER: Donnelly C 

PROVIDER: S-EPMC10906399 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature