The causal effect of obesity on concomitant exotropia: A lifecourse Mendelian randomization study.

ABSTRACT: Obesity is now a significant global public health issue. Limited understanding exists regarding the association between obesity and concomitant exotropia. Our objective was to identify the causal relationship between lifecourse obesity, including birth weight, childhood body mass index (BMI), and adult BMI, and the risk of concomitant exotropia. We used a two-sample Mendelian randomization (MR) strategy to examine the causal relationship with inverse-variance weighted method as the primary MR analysis. We carried out sensitivity analyses to evaluate the accuracy and robustness of our findings. Also, we performed reverse-direction MR analysis to eliminate the possibility of reverse causality. Childhood BMI, as opposed to birth weight or adult BMI, had a significant impact on the risk of con

SUBMITTER: Liu C 

PROVIDER: S-EPMC10906616 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature