Neuroinvasive Bacillus cereus Infection in Immunocompromised Hosts: Epidemiologic Investigation of 5 Patients With Acute Myeloid Leukemia.

ABSTRACT:

Background

Bacillus cereus is a ubiquitous gram-positive rod-shaped bacterium that can cause sepsis and neuroinvasive disease in patients with acute leukemia or neutropenia.

Methods

A single-center retrospective review was conducted to evaluate patients with acute leukemia, positive blood or cerebrospinal fluid test results for B cereus, and abnormal neuroradiographic findings between January 2018 and October 2022. Infection control practices were observed, environmental samples obtained, a dietary case-control study completed, and whole genome sequencing performed on environmental and clinical Bacillus isolates.

Results

Five patients with B cereus neuroinvasive disease were identified. All patients had acute myeloid leukemia (AML), were re

SUBMITTER: Little JS 

PROVIDER: S-EPMC10906701 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature