Distinct gene clusters drive formation of ferrosome organelles in bacteria.

ABSTRACT: Cellular iron homeostasis is vital and maintained through tight regulation of iron import, efflux, storage and detoxification^1-3. The most common modes of iron storage use proteinaceous compartments, such as ferritins and related proteins^4,5. Although lipid-bounded iron compartments have also been described, the basis for their formation and function remains unknown^6,7. Here we focus on one such compartment, herein named the 'ferrosome', that was previously observed in the anaerobic bacterium Desulfovibrio magneticus⁶. Using a proteomic approach, we identify three ferrosome-associated (Fez) proteins that are responsible for forming ferrosomes in D. magneticus. Fez proteins are encoded in a putative operon and include FezB, a P_1B-6-ATPa

SUBMITTER: Grant CR 

PROVIDER: S-EPMC10906721 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature