Cellular receptors for mammalian viruses.

ABSTRACT: The interaction of viral surface components with cellular receptors and other entry factors determines key features of viral infection such as host range, tropism and virulence. Despite intensive research, our understanding of these interactions remains limited. Here, we report a systematic analysis of published work on mammalian virus receptors and attachment factors. We build a dataset twice the size of those available to date and specify the role of each factor in virus entry. We identify cellular proteins that are preferentially used as virus receptors, which tend to be plasma membrane proteins with a high propensity to interact with other proteins. Using machine learning, we assign cell surface proteins a score that predicts their ability to function as virus receptors. Our results al

SUBMITTER: Valero-Rello A 

PROVIDER: S-EPMC10906839 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature