What to Expect With Pregnant or Postpartum Prescribing of Extended-Release Buprenorphine (CAM2038).

ABSTRACT: Weekly and monthly CAM2038 (Brixadi^®) extended-release subcutaneous buprenorphine (XR bup) has been available in Europe and Australia for several years and was approved by the Food and Drug Administration in May 2023. Little is known about the clinical experience of patients and providers using this new medication during prenatal care. Two cases of pregnant persons with opioid use disorder receiving weekly XR bup in an ongoing randomized multi-site outpatient clinical trial are presented along with a brief review of the pharmacology and literature on XR bup formulations. The cases in pregnancy illustrate how treatment with the weekly formulation is initiated including how to make dose adjustments, which may be necessary given the longer half-life; it takes 1 month to achieve ste

SUBMITTER: Lofwall MR 

PROVIDER: S-EPMC10906993 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature