Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer's disease.

ABSTRACT: There is increased interest in developing markers reflecting microstructural changes that could serve as outcome measures in clinical trials. This is especially important after unexpected results in trials evaluating disease-modifying therapies targeting amyloid-β (Aβ), where morphological metrics from MRI showed increased volume loss despite promising clinical treatment effects. In this study, changes over time in cortical mean diffusivity, derived using diffusion tensor imaging, were investigated in a large cohort (n = 424) of non-demented participants from the Swedish BioFINDER study. Participants were stratified following the Aβ/tau (AT) framework. The results revealed a widespread increase in mean diffusivity over time, including both temporal and parietal cortical regions, in Aβ-posi

SUBMITTER: Spotorno N 

PROVIDER: S-EPMC10907088 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature