Dataset Information

The 6-minute Run Test: Validation and Reference Equations for Adults.

ABSTRACT: Endurance performance tests directly measuring cardiorespiratory fitness are complex, but field tests indirectly assessing maximum oxygen uptake (VO_2max) are an alternative. This study aimed to validate the 6-minute run test in adults, comparing it to the established shuttle run test, and to create reference equations. The cross-over design involved healthy adults aged 18-65 undertaking both tests, separated by a two-hour interval. The 6-minute run test required participants to run around a volleyball court for six minutes, aiming to maximize distance covered. The shuttle run involved participants covering 20 meters in defined time intervals at increasing speeds. Parameters measured included 6-minute run test distance, heart rates, calculated maximum oxygen uptake during the shuttle run, and total shuttle count. The study enrolled 250 participants (134 men and 116 women). Men averaged 1195.7 m (SD=161.4), while women averaged 1051.2 m (SD=148.0) in six minutes. The strongest correlation was found between the distance covered in the 6-minute run test and the total shuttle count (r=0.91, p<0.001). Two predictive models for 6-minute run test distance were developed and normative values for different sex-specific age clusters were established. The study showed that the 6-minute run test is valid as a practical endurance test for adults aged 18-65.

SUBMITTER: Leuschner M

PROVIDER: S-EPMC10907109 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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The 6-minute Run Test: Validation and Reference Equations for Adults.

Leuschner Malte M Grauduszus Martin M Friesen David D Ferrari Nina N Klaudius Marlen M Joisten Christine C

International journal of sports medicine 20231219 3

Endurance performance tests directly measuring cardiorespiratory fitness are complex, but field tests indirectly assessing maximum oxygen uptake (VO<sub>2max</sub>) are an alternative. This study aimed to validate the 6-minute run test in adults, comparing it to the established shuttle run test, and to create reference equations. The cross-over design involved healthy adults aged 18-65 undertaking both tests, separated by a two-hour interval. The 6-minute run test required participants to run ar ...[more]

PMID: 38113901

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Project description:ImportanceRace and ethnicity are routinely used to inform pulmonary function test (PFT) interpretation. However, there is no biological justification for such use, and it may reinforce health disparities.ObjectiveTo compare the PFT interpretations produced with race-neutral and race-specific equations.Design, setting, and participantsIn this cross-sectional study, race-neutral reference equations recently developed by the Global Lung Function Initiative (GLI) were used to interpret PFTs performed at an academic medical center between January 2010 and December 2020. The interpretations produced with these race-neutral reference equations were compared with those produced using the race and ethnicity-specific reference equations produced by GLI in 2012. The analysis was conducted from April to October 2022.Main outcomes and measuresThe primary outcomes were differences in the percentage of obstructive, restrictive, mixed, and nonspecific lung function impairments identified using the 2 sets of reference equations. Secondary outcomes were differences in severity of these impairments.ResultsPFTs were interpreted from 2722 Black (686 men [25.4%]; mean [SD] age, 51.8 [13.9] years) and 5709 White (2654 men [46.5%]; mean [SD] age, 56.4 [14.3] years) individuals. Among Black individuals, replacing the race-specific reference equations with the race-neutral reference equations was associated with an increase in the prevalence of restriction from 26.8% (95% CI, 25.2%-28.5%) to 37.5% (95% CI, 35.7%-39.3%) and of a nonspecific pattern of impairment from 3.2% (95% CI, 2.5%- 3.8%) to 6.5% (95% CI, 5.6%-7.4%) and no significant change in the prevalence of obstruction (19.9% [95% CI, 18.4%-21.4%] vs 19.5% [95% CI, 18.0%-21.0%]). Among White individuals, replacing the race-specific reference equations with the race-neutral reference equations was associated with a decrease in the prevalence of restriction from 22.6% (95% CI, 21.5%-23.6%) to 18.0% (95% CI, 17.0%-19.0%), a decrease in the prevalence of a nonspecific pattern of impairment from 8.7% (95% CI, 7.9%-9.4%) to 4.0% (95% CI, 3.5%-4.5%), and no significant change in the percentage with obstruction from 23.9% (95% CI, 22.8%-25.1%) to 25.1% (95% CI, 23.9%- 26.2%). The race-neutral reference equations were associated with an increase in severity in 22.8% (95% CI, 21.2%-24.4%) of Black individuals and a decrease in severity in 19.3% (95% CI, 18.2%-20.3%) of White individuals vs the race-specific reference equations.Conclusions and relevanceIn this cross-sectional study, the use of race-neutral reference equations to interpret PFTs resulted in a significant increase in the number of Black individuals with respiratory impairments along with a significant increase in the severity of the identified impairments. More work is needed to quantify the effect these reference equations would have on diagnosis, referral, and treatment patterns.

Project description:BackgroundThe six-minute walk test (6MWT) is a safe, simple, inexpensive tool for evaluating the functional exercise capacity of patients with chronic respiratory disease. However, there is a lack of standard reference equations for the six-minute walk distance (6MWD) in the healthy Chinese population aged 18-59 years.AimsThe purposes of the present study were as follows: 1) to measure the anthropometric data and walking distance of a sample of healthy Chinese Han people aged 18-59 years; 2) to construct reference equations for the 6MWD; 3) to compare the measured 6MWD with previously published equations.MethodThe anthropometric data, demographic information, lung function, and walking distance of Chinese adults aged 18-59 years were prospectively measured using a standardized protocol. We obtained verbal consent from all the subjects before the test, and the study design was approved by the ethics committee of Wenzhou People's Hospital. The 6MWT was performed twice, and the longer distance was used for further analysis.ResultsA total of 643 subjects (319 females and 324 males) completed the 6MWT, and average walking distance was 601.6±55.51 m. The walking distance was compared between females and males (578±49.85 m vs. 623±52.53 m; p < 0.0001) and between physically active subjects and sedentary subjects (609.3±56.17 m vs. 592±53.23 m; p < 0.0001). Pearson's correlation indicated that the 6MWD was significantly correlated with various demographic and the 6MWT variables, such as age, height, weight, body mass index (BMI), heart rate after the test and the difference in the heart rate before and after the test. Stepwise multiple regression analysis showed that age and height were independent predictors associated with the 6MWD. The reference equations from white, Canadian and Chilean populations tended to overestimate the walking distance in our subjects, while Brazilian and Arabian equations tended to underestimate the walking distance. There was no significant difference in the walking distance between Korean reference equations and the results of the current study.ConclusionIn summary, age and height were the most significant predictors of the 6MWD, and regression equations could explain approximately 34% and 28% of the distance variance in the female and male groups, respectively.

Dataset Information

The 6-minute Run Test: Validation and Reference Equations for Adults.

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The 6-minute Run Test: Validation and Reference Equations for Adults.

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