Prognostic impact of the findings of the genetic test in left dominant arrhythmogenic cardiomyopathy.

ABSTRACT:

Background

The diagnosis of left dominant arrhythmogenic cardiomyopathy (LDAC) is sometimes complex. The Padua group recently published a document with criteria to identify patients with LDAC, requiring a compatible genetic variant for diagnosis. Due to the gaps in the knowledge of the role of genetics in its pathogenesis, our objective is to describe the findings of the genetic test in patients with LDAC in our center and its prognostic impact.

Methods

Single-center prospective cohort study, in which we recruited 77 patients diagnosed with LDAC or biventricular arrhythmogenic cardiomyopathy according to the criteria of Sen-Chowdhry et al.

Results

We obtained a positive result in the genetic test in 53.2 %. The desmoplakin gene was the most affected (16.9 %). The mean

SUBMITTER: Garcia-Cano L 

PROVIDER: S-EPMC10907150 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature