IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria.

ABSTRACT: Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that express an invariant T cell receptor α chain and contribute to bridging innate and acquired immunity with rapid production of large amounts of cytokines after stimulation. Among effecter subsets of iNKT cells, follicular helper NKT (NKT_FH) cells are specialized to help B cells. However, the mechanisms of NKT_FH cell differentiation remain to be elucidated. In this report, we studied the mechanism of NKT_FH cell differentiation induced by pneumococcal surface protein A and α-galactosylceramide (P/A) vaccination. We found that Gr-1⁺ cells helped iNKT cell proliferation and NKT_FH cell differentiation in the spleen by producing interleukin-27 (IL-27) in the early phas

SUBMITTER: Kamii Y 

PROVIDER: S-EPMC10907256 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature