Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial.

ABSTRACT:

Purpose

Acute kidney disease (AKD) is a significant health care burden worldwide. However, little is known about this complication after major surgery.

Methods

We conducted an international prospective, observational, multi-center study among patients undergoing major surgery. The primary study endpoint was the incidence of AKD (defined as new onset of estimated glomerular filtration rate (eCFR) < 60 ml/min/1.73 m² present on day 7 or later) among survivors. Secondary endpoints included the relationship between early postoperative acute kidney injury (AKI) (within 72 h after major surgery) and subsequent AKD, the identification of risk factors for AKD, and the rate of chronic kidney disease (CKD) progression in patients with pre-existing CKD.

Results

We stu

SUBMITTER: Meersch M 

PROVIDER: S-EPMC10907445 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature