Nutritional ketosis as treatment for alcohol withdrawal symptoms in female C57BL/6J mice.

ABSTRACT: Upon both acute and prolonged alcohol intake, the brain undergoes a metabolic shift associated with increased acetate metabolism and reduced glucose metabolism, which persists during abstinence, putatively leading to energy depletion in the brain. This study evaluates the efficacy of ketogenic treatments to rescue psychiatric and neurochemical alterations during long-term alcohol withdrawal. Female mice were intermittently exposed to alcohol vapor or air for three weeks, during which mice were introduced to either a ketogenic diet (KD), control diet supplemented with ketone ester (KE) or remained on control diet (CD). Withdrawal symptoms were assessed over a period of four weeks followed by re-exposure using several behavioral and biochemical tests. Alcohol-exposed mice fed CD displayed lo

SUBMITTER: Tonetto S 

PROVIDER: S-EPMC10907582 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature