Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.

ABSTRACT: During long-duration spaceflight, astronauts experience headward fluid shifts and expansion of the cerebral perivascular spaces (PVS). A major limitation to our understanding of the changes in brain structure and physiology induced by spaceflight stems from the logistical difficulties of studying astronauts. The current study aimed to determine whether PVS changes also occur on Earth with the spaceflight analog head-down tilt bed rest (HDBR). We examined how the number and morphology of magnetic resonance imaging-visible PVS (MV-PVS) are affected by HDBR with and without elevated carbon dioxide (CO₂). These environments mimic the headward fluid shifts, body unloading, and elevated CO₂ observed aboard the International Space Station. Additionally, we sought to understa

SUBMITTER: Richmond SB 

PROVIDER: S-EPMC10907584 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature