Do calcium channel blockers applied to cardiomyocytes cause increased channel expression resulting in reduced efficacy?

ABSTRACT: In the initial hours following the application of the calcium channel blocker (CCB) nifedipine to microtissues consisting of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), we observe notable variations in the drug's efficacy. Here, we investigate the possibility that these temporal changes in CCB effects are associated with adaptations in the expression of calcium ion channels in cardiomyocyte membranes. To explore this, we employ a recently developed mathematical model that delineates the regulation of calcium ion channel expression by intracellular calcium concentrations. According to the model, a decline in intracellular calcium levels below a certain target level triggers an upregulation of calcium ion channels. Such an upregulation, if instigated by a CCB, wou

SUBMITTER: Jæger KH 

PROVIDER: S-EPMC10907638 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature