Decreased circulating myeloid-derived suppressor cell count at the engraftment is one of the risk factors for multiple myeloma relapse after autologous hematopoietic stem cell transplantation.

ABSTRACT: Recent studies demonstrated that myeloid-derived suppressor cells (MDSCs) are involved in the pathogenesis and progression of multiple myeloma (MM). Nevertheless, data on the quantitative and functional changes in MDSCs during standard MM treatment remain poorly understood. Here, we determined that monocytic MDSCs (M-MDSC; CD14⁺HLA-DR^low/-) and granulocytic MDSCs (PMN-MDSC; Lin^-HLA-DR^-CD33⁺CD66b⁺) in MM patients in remission following induction therapy (IT) were significantly increased, while early MDSCs (E-MDSCs; Lin^-HLA-DR^-CD33⁺CD66b^-) were decreased compared to the donor group. In progression, MM patients had the most pronounced decrease in E-MDSCs and enhanced levels of PMN-MDS

SUBMITTER: Tyrinova T 

PROVIDER: S-EPMC10907647 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature