The development of early human lymphatic vessels as characterized by lymphatic endothelial markers.

ABSTRACT: Lymphatic vessel development studies in mice and zebrafish models have demonstrated that lymphatic endothelial cells (LECs) predominantly differentiate from venous endothelial cells via the expression of the transcription factor Prox1. However, LECs can also be generated from undifferentiated mesoderm, suggesting potential diversity in their precursor cell origins depending on the organ or anatomical location. Despite these advances, recapitulating human lymphatic malformations in animal models has been difficult, and considering lymphatic vasculature function varies widely between species, analysis of development directly in humans is needed. Here, we examined early lymphatic development in humans by analyzing the histology of 31 embryos and three 9-week-old fetuses. We found that human e

SUBMITTER: Yamaguchi S 

PROVIDER: S-EPMC10907744 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature