Autoimmune diseases exhibit shared alterations in the gut microbiota.

ABSTRACT:

Objective

Accumulating evidence from microbial studies have highlighted the modulatory roles of intestinal microbes in numerous human diseases, however, the shared microbial signatures across different diseases remain relatively unclear.

Methods

To consolidate existing knowledge across multiple studies, we performed meta-analyses of 17 disease types, covering 34 case-control datasets of 16S rRNA sequencing data, to identify shared alterations among different diseases. Furthermore, the impact of a microbial species, Lactobacillus salivarius, was established in a dextran sodium sulphate-induced colitis model and a collagen type II-induced arthritis mouse model.

Results

Microbial alterations among autoimmune diseases were substantially more consistent compared with that

SUBMITTER: Wang T 

PROVIDER: S-EPMC10907812 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature