Predictors of DAPSA28 remission in patients with psoriatic arthritis initiating a first TNF inhibitor: results from 13 European registries.

ABSTRACT:

Objectives

In bio-naïve patients with PsA initiating a TNF inhibitor (TNFi), we aimed to identify baseline predictors of Disease Activity index for PsA in 28 joints (DAPSA28) remission (primary objective) and DAPSA28 moderate response at 6 months, as well as drug retention at 12 months across 13 European registries.

Methods

Baseline demographic and clinical characteristics were retrieved and the three outcomes investigated per registry and in pooled data, using logistic regression analyses on multiply imputed data. In the pooled cohort, selected predictors that were either consistently positive or negative across all three outcomes were defined as common predictors.

Results

In the pooled cohort (n = 13 369), 6-month proportions of remission, moderate response and 12-m

SUBMITTER: Linde L 

PROVIDER: S-EPMC10907817 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature