STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway.

ABSTRACT: HCC is a globally high-incidence malignant tumour, and its pathogenesis is still unclear. Recently, STRN3 has been found to be elevated in various tumours, but its expression and biological functions in HCC have not been studied. In the study, clinical correlation analysis was performed on 371 liver cancer patients from TCGA database and liver cancer tissues and normal tissues from the GEO database. qRT-PCR and western blotting were used to detect relevant proteins in cells, and CCK8 and colony formation experiments were performed to analyse cell proliferation ability. Transwell and wound healing experiments were performed to detect cell invasion ability, and flow cytometry was used to detect cell apoptosis. Single-cell sequencing data and multiple immunofluorescence were analysed for the

SUBMITTER: Zhu J 

PROVIDER: S-EPMC10907822 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature