Highly sensitive and simultaneous detection of ascorbic acid, dopamine, and uric acid using Pt@g-C₃N₄/N-CNTs nanocomposites.

ABSTRACT: The detection of ascorbic acid (AA), dopamine (DA), and uric acid (UA) is crucial for understanding and managing various illnesses. In this research, Pt@g-C₃N₄ nanoparticles were synthesized via hydrothermal method and combined with N-doped carbon nanotubes (N-CNTs). The Pt@g-C₃N₄/N-CNTs-modified glassy carbon (GC) electrode was fabricated as an electrochemical sensor for the determination of AA, DA, and UA. The linear response range of AA, DA, and UA in the optimal condition was 100-3,000 μM, 1-100 μM, and 2-215 μM boasting a low detection limit (S/N = 3) of 29.44 μM (AA), 0.21 μM (UA), and 2.99 μM (DA), respectively. Additionally, the recoveries of AA, DA, and UA in serum sample were 100.4%-106.7%. These results corroborate the feasibility of the proposed method for the simultaneous, sensitive, and reliable detection of AA, DA, and UA. Our Pt@g-C₃N₄/N-CNTs/GC electrode can provide a potential strategy for disease diagnosis and health monitoring in clinical settings.

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10907839 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature